Did you know you can lock items in your inventory when not at a vendor?
Hold Alt and left click the item. Then hold CTRL and hit the letter T to toggle lock on/off.
You can also lock them at a vendor by clicking the lock on the item.
You can equip locked items. They stay locked as you take them off and put them back on.
I personally lock everything I want to keep. I feel that if a hacker comes on my account one day, hes gonna have to do a lot of work to steal my stuff!